Análisis de la Cinética de Difusión en Hidrogeles sintetizados mediante Radiación Gamma
Keywords:
hidrogel, hinchamiento, mecanismos de difusión, radiación gammaAbstract
Hydrogels are cross-linked polymeric networks, which have the ability to change their volume depending on their environment. They have several applications; one of them is as a drug delivery system, which involves the hydration and dehydration of the material. Therefore, in this work we carried out a kinetics and diffusion mechanisms analysis, which occur in hydrogels during these processes. The hydrogels were made by using gamma radiation at several absorbed doses. Then, we performed swelling and dehydration tests that were used to calculate the swelling and dehydration percentages, respectively, as well as the diffusion coefficient and the diffusional exponent. The results showed that as the dose necessary to obtain the crosslinks increased, the swelling and dehydration capacity of the matrix as well as the diffusion coefficient decreased. The kinetic analysis showed the hydrogels of 25 kGy have anomalous diffusion mechanism, while those 30 kGy and 35 kGy show the diffusion Fickian mechanism. In conclusion, these assays allowed us to understand the kinetic performance of the polymeric matrix / solvent system at different absorbed doses in order to consider these mechanisms when different active ingredients are used
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